Tianeptine (Stablon, Coaxil, Tatnol)

Tianeptine is an atypical antidepressant that is used in Europe and other parts of the world. It is manufactured by Servier Pharmaceutics in France, and is not available in the US. Pharmos has the drug in its development pipeline as a treatment for IBS, but is not actively developing it at this time.

The Bottom Line: What You Really Need to Know


Tianeptine is indicated for the treatment of depression. It is also used to treat anxiety and panic attacks. The medication has other uses, including the treatment of asthma, depression with erectile dysfunction, ADD and ADHD and fibromyalgia. It is being considered as a treatment for IBS in the US.

Tianeptine decreases anxiety and brightens mood without either oversedation or overstimulation.


The usual dose of tianeptine is 12.5 mg three times a day before meals. There is no need to gradually increase the dose or to taper it before discontinuation.

How tianeptine works

Tianeptine is a modified tricyclic antidepressant. In contrast to other antidepressants, tianeptine enhances serotonin reuptake (it's an SSRE medication), and it works mostly in the cerebral cortex and hippocampus of the brain.

The development of tianeptine is the result of exciting new brain research that focuses on the architecture of the brain in addition to neurotransmission. Tianeptine enhances "neuroplasticity," which has to do with brain architecture. Specifically, the actions of tianeptine are:

Side Effects

Side effects are rare and are usually mild to moderate in severity. They can include:


Tianeptine may interact with monamine oxidase inhibiting antidepressants (MAOIs).


Tianeptine should not be taken with MAOIs.

It should not be taken by children under the age of 15.

It should not be taken by women who are or wish to become pregnant or during lactation.

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